Saturday, January 27, 2007

The Energy Crisis was "solved" in 1930!

The question was;
Is it Cause or Effect?

Unfortunately a leading scientist, the famous Hans Krebs (right), denounced the Warburg Hypothesis, and the older Otto Warburg (left) never did manage to have his idea taken seriously. Interestingly Hans was Otto's assistant at the Kaiser-Wilhelm-Gesellschaft (now renamed the Max Planck Institute) until 1930, which is the time when Otto was developing his ground breaking concept. Later in his life Hans would continue to denounce the hypothesis. (I wonder was there a falling out?) Otto's idea was simple; The source of energy is the Cause! I am of course referring to Cancer. Otto was proposing that the fact that cancer cells switch to glycolosis from their normal energy source provided by the mitochondria was a defining property of the cancer cell. Had this idea been accepted back in the 1930's, perhaps we would already have the cure! As the key trick, lies in the fact that another function of the Mitochondria is to trigger an abnormal cells self destruction (an activity known as Apoptosis).

A recent article in New Scientist 20th January has highlighted that a very simple compound, namely dichloroethanoic acid (aka Dichloroacetate (DCA)) has the potential of switching a cells energy source back to the Mitochondria, resulting in the other Mitochondrial function of apoptosis operating.


The problem is that the capitalistic system of Invention-Patent-Reward will not work with a compound already known to exist and thus not patentable. Yet the clinical trials do need to occur as this is after all an acid, and earlier trials have shown that DCA is corrosive and destroys the tissue of mucous membrane and upper respiratory tract.

Any one care to invent a new disease eradication model other than the standard selfish/greed based model we use today?

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